医疗特长：中山大学附属第一医院转化医学研究中心副研究员，林水宾研究员团队。入选“广东特支计划”青年拔尖人才。从事代谢重编程与翻译异常调控肿瘤进展的功能和机制研究，以（共同）通讯/第一作者在Science Translational Medicine (封面文章), Science Advances, EMBO Journal, Cell Reports (2篇), Drug Resistance Updates, Advanced Science (2篇)等期刊发表多篇研究论文。
代表性成果
1. Wang Z(#), Di Y(#), Wen X(#), Liu Y(#), Ye L, Zhang X, Qin J, Wang Y, Chu H, Li G(*), Zhang W(*), Wang X(*), He W(*). NIT2 dampens BRD1 phase separation and restrains oxidative phosphorylation to enhance chemosensitivity in gastric cancer. Science Translational Medicine. 2024 Nov 20;16(774): eado8333. (Cover article)
2. Wang Z(#)(*), Di Y(#), Ye L(#), Fang W(#), Wen X, Zhang X, Qin J, Wang Y, Zhu Z(*), He W(*), Chen Y(*). NANS suppresses NF-κB signaling to promote ferroptosis by perturbing iron homeostasis. Cell Reports. 2025 May 27;44(5):115701.
3. Wen X(#),Qin J(#), Zhang X, Ye L, Wang Y, Yang R, Di Y(*), He W(*),Wang Z(*). MEK-mediated CHPF2 phosphorylation promotes colorectal cancer cell proliferation and metastasis by activating NF-κB signaling. Cancer Letters. 2024 Jan 21:216644.
4. Di Y(#),Wang Z(#)(*), Xiao J(#), Zhang X(#), Ye L, Wen X, Qin J, Lu L(*), Wang X(*), He W(*). ACSL6-activated IL18R1-NF-κB promotes IL18-mediated tumor immune evasion and tumor progression. Science Advances. 2024 Sep 20;10(38): eadp0719.
5. Zhang X(#), Di Y(#), Wang Y(#), Qin J, Ye L, Wen X, Ke Z(*), Wang Z(*), He W(*). SIRT5-mediated desuccinylation of PPA2 enhances adaptation to hypoxic stress to facilitate colorectal cancer metastasis. EMBO Journal. 2025 Mar 31.
6. Di Y(#), Jing X(#), Hu L(#), Wen X, Ye L, Zhang X, Qin J, Ye J, Lin R(*), Wang Z(*), He W(*). The c-MYC-WDR43 signalling axis promotes chemoresistance and tumour growth in colorectal cancer by inhibiting p53 activity. Drug Resistance Updates. 2023 Jan; 66: 100909.
7. Di Y, Zhang X, Wen X, Qin J, Ye L, Wang Y, Song M(*), Wang Z(*), He W(*). MAPK Signaling-Mediated RFNG Phosphorylation and Nuclear Translocation Restrain Oxaliplatin-Induced Apoptosis and Ferroptosis. Advanced Science. 2024 Aug 9:e2402795.
8. Wang Z, Sheng C, Kan G, Yao C, Geng R, Chen S(*). RNAi Screening Identifies that TEX10 Promotes the Proliferation of Colorectal Cancer Cells by Increasing NF-κB Activation. Advanced Science. 2020 July; 7(17): 2000593.
9. Wang Z(#), Sheng C(#), Yao C(#), Chen H, Wang D, Chen S(*). The EF-Hand Protein CALML6 Suppresses Antiviral Innate Immunity by Impairing IRF3 Dimerization. Cell Reports. 2019 Jan; 26(5): 1273-85.
10. Sheng C(#), Wang Z(#), Yao C(#), Chen H, Kan G, Wang D, Chen H(*), Chen S(*). CALML6 controls TAK1 ubiquitination and confers protection against acute inflammation. Journal of Immunology. 2020 Apr; 204(11): 3008-18.
科研项目
1. 国家自然科学基金面上项目，2026-2029，主持
2. “广东特支计划”青年拔尖人才项目，2026-2028, 主持
3. 国家自然科学基金青年科学基金项目，2023-2025，主持
4. 广东省自然科学基金面上项目，2024-2026，主持
5. 中国博士后科学基金特别资助项目，2024-2025，主持
6. 中国博士后科学基金面上项目，2022-2023，主持
7. 华南恶性肿瘤防治全国重点实验室开放课题，2025-2026，主持
